Growth factor therapy to prevent postinfarction heart failure
نویسندگان
چکیده
منابع مشابه
Gene transfer of hepatocyte growth factor attenuates postinfarction heart failure.
BACKGROUND Despite advances in surgical and percutaneous coronary revascularization, ongoing ischemia that is not amenable to standard revascularization techniques is a major cause of morbidity and mortality. Hepatocyte Growth Factor (HGF) has potent angiogenic and anti-apoptotic activities, and this study evaluated the functional and biochemical effects of HGF gene transfer in a rat model of p...
متن کاملPostinfarction Gene Therapy Against Transforming Growth Factor- Signal Modulates Infarct Tissue Dynamics and Attenuates Left Ventricular Remodeling and Heart Failure
Background—Fibrosis and progressive failure are prominent pathophysiological features of hearts after myocardial infarction (MI). We examined the effects of inhibiting transforming growth factor(TGF) signaling on post-MI cardiac fibrosis and ventricular remodeling and function. Methods and Results—MI was induced in mice by left coronary artery ligation. An adenovirus harboring soluble TGFtype I...
متن کاملTargeting endoglin, an auxiliary transforming growth factor β coreceptor, to prevent fibrosis and heart failure.
Over the past 25 years, cardiovascular medicine has witnessed substantial progress in our understanding of the molecular pathogenesis, genetic causes, as well as the design of more efficacious therapeutic interventions. These advances have resulted in the dramatic reduction in the mortality of heart disease, especially in industrialized societies. Notwithstanding, both the prevalence and incide...
متن کاملEchocardiographic detection of congestive heart failure in postinfarction rats.
In studies of congestive heart failure (CHF) treatment, it is essential to select animals with a similar degree of cardiac dysfunction. However, this is difficult to establish without hemodynamic evaluation in rat postinfarction-induced CHF. This study aimed to diagnose CHF in long-term follow-up postinfarction rats using only echocardiographic criteria through a J-tree cluster analysis and Fis...
متن کاملPostinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure.
BACKGROUND Fibrosis and progressive failure are prominent pathophysiological features of hearts after myocardial infarction (MI). We examined the effects of inhibiting transforming growth factor-beta (TGF-beta) signaling on post-MI cardiac fibrosis and ventricular remodeling and function. METHODS AND RESULTS MI was induced in mice by left coronary artery ligation. An adenovirus harboring solu...
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ژورنال
عنوان ژورنال: Proceedings for Annual Meeting of The Japanese Pharmacological Society
سال: 2018
ISSN: 2435-4953
DOI: 10.1254/jpssuppl.wcp2018.0_sy4-4